The park covers approximately 7,050 square kilometres (2,720 sq mi). It is located in the southwest section of the Neuquén and northwest section of the Río Negro provinces, bordering with Chile. The park has two zones: the park and the natural reserve with development concentrated in the reserve. The largest city and a base for tourism is San Carlos de Bariloche, which is surrounded by the park. San Carlos de Bariloche is the main hub when visiting the lake, and is known as the "Gateway to Patagonia", the "Chocolate Capital" and the "Honeymoon Capital" of Argentina. However, the city and other settlements are zoned outside the limits of the park. A further subzoning into the north, south and southern zones has been implemented with an exclusive recreational area named the Cerro Cathedral. Villa La Angostura is another lakeside resort also within the boundaries of the park.

The earliest discovery of Nahuel Huapi by the non-indigenous peoples is linked to the conquest of Chile. In the summer of 1552–1553, the Governor of Chile Pedro de Valdivia sent Francisco de Villagra to explore the area east of the Andes at the latitudes of the city of Valdivia. Francisco de Villagra crossed the Andes through Mamuil Malal Pass and headed south until reaching Limay River in the vicinity of Nahuel Huapi Lake.

When someday comes you'll need to get in.

When someday comes you'll need to be able to get around.